Systems Biology of Human Aging - Network Model


Systems Biology of Human Aging Network Model Biochemical and Physiological Interactions

Please scroll down past the image to see: Getting started with this Network Diagram; Acknowledgements and Citations; This network model has been reviewed by others; How to order poster prints; How to download a printable PDF; Copyright and Presentation History. How to suggest changes and improvments;

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GETTING STARTED WITH THIS NETWORK DIAGRAM: This symbolic diagram is not really a picture of a cell. It changes in scale from molecular events at the top, through whole cell activities in the middle, to tissue, organ, and whole body diseases at the bottom. Thick horizontal borders separate transitions in scale. Intracellular events are described on the top left. Extracellular matrix and blood are described on the top right. Colors have meaning, as indicated in the "Color Key". Shapes have meanings described in the "Shape Key". A table of abbreviations is on the lower left. Solid boxes represent physical materials. Slanted-roof boxes represent increase or decrease in quantities during aging. Hatched boxes represent activities or processes. Thin arrows represent causal sequences of events. Thick arrows represent physical transport or movement. A circle with an "X" inside represents inhibition of the indicated process; this might mark a candidate target for therapeutic intervention. Tags on the outsides represent environmental factors or external interventions.


ACKNOWLEDGEMENTS and CITATIONS: This Network Model of Human Senescence was compiled and arranged by John D. Furber, based upon information in research reports from many scientists. References and links to more information about these topics may be found at: http://LegendaryPharma.com/senescence.html Keywords may be searched at: PubMed scirus Google Scholar A very good recent review of aging mechanisms was published in the journal, Nature by Jan Vijg & Judith Campisi. (2008) Puzzles, promises and a cure for ageing. Nature, 454, 1065-1071. Special thanks go to the following scientists for their helpful suggestions on earlier versions of this network diagram, which were used to update it to its current form: Alexandra Stolzing, Aubrey de Grey, Pat Langley, Ulf T. Brunk, Alexei Terman, Caleb Finch, George M. Martin, Mark A. Smith, Richard G. Cutler, Florian Muller, Robert Bradbury, James Joseph, Mark P. Mattson, Allen Herbst, Arthur Balin, Bill Vaughan, Juraj Dzifcak, Stanley Primmer, Stephen A. Racunas, Michael Verdicchio.


This Network Model has been reviewed by others: This network model was one of several which formed the basis of discussion at the Symposium on the Systems Biology of Human Aging at the National Institute on Aging, Baltimore, Maryland, 8-9 December 2009. Science and health writer Joyce Wall featured this network model in her article, "Aging and Antioxidants: finding a magic bullet in a biological battlefield of free radicals", Examiner.com, 25 October 2009. This network model was one of several which formed the basis of discussion at the Symposium on the Systems Biology of Aging at Arizona State University, 6-7 December 2008. http://circas.asu.edu/symposia/aging/ Louisa Dalton featured this network model in "Assembling The Aging Puzzle: Computation Helps Connect the Pieces," Biomedical Computation Review, Spring 2008. http://biomedicalcomputationreview.org/4/2/index.html Science fiction writer Bruce Sterling reviewed this Systems Biology Network Model of Aging Wall Chart on his *Wired* blog, "Beyond the Beyond". blog.wired.com/sterling/ November 18, 2007 \| 1:51:26 pm. VisualComplexity.com intends to be a unified resource space for anyone interested in the visualization of complex networks. This network model is reveiwed at: www.visualcomplexity.com/vc/project.cfm?id=521 Cool Infographics is a blog about infographics that turn data into information. This network model was reviewed 24 Nov 2007: coolinfographics.blogspot.com/2007_11_01_archive.html Ouroboros "Research in the biology of aging." Ouroboros reviewed this network model on 13 Aug 2007: ouroboros.wordpress.com/2007/08/13/molecular-events-of-aging-posterflowchart/#comment-39549 GrailSearch.org "Researching Engineered Longevity. Searching for emergent engineering concepts for the sake of longevity in systems biology, informatics, computational chemistry, genetics, and biochemistry." GrailSearch reviewed this network model on 13 Aug 2007: grailsearch.org/?q=node/50 ORDERING POSTER PRINTS: Full-color copies of this chart, printed on white background, may be ordered from Legendary Pharmaceuticals. Large Wall Chart The network is printed on a large sheet, 36 x 48 inches (91 x 121 cm). The descriptive information is printed on two smaller sheets. Shipped rolled in a 36-inch mailing tube. $60 each plus $20 for shipping in the United States. Please enquire for foreign orders. Medium Wall Chart The network is printed on a large sheet, 24 x 36 inches (61 x 91 cm). The descriptive information is printed on two smaller sheets. Shipped rolled in a 25-inch mailing tube. $40 each plus $15 for shipping in the United States. Please enquire for foreign orders. Small Wall Chart The network is printed on a tabloid sheet of 11 x 15 inch white paper (28 x 38 cm). The descriptive information is printed on two separate sheets. Shipped rolled in a 12-inch mailing tube. At this reduced size, the text is very small, and difficult to read. $5 each plus $7 per order for packing & shipping. Please enquire for foreign orders. Artist signature: Upon request, the artist will autograph your copy (no extra charge). Sponsored Printing: Your organization or company can cover the cost of printing a batch of posters on large-format paper. An acknowledgment and your logo can be printed on the posters. This will lower the cost to scientists, students, and interested individuals. You can also distribute posters directly. To enquire regarding larger sizes, quantity discounts, classroom use, sponsorship, or foreign addresses, please email: johnfurber at LegendaryPharma com Please make checks payable to "Legendary Pharmaceuticals", and send to: Legendary Pharmaceuticals PO BOX 14200 Gainesville FL 32604-2200, USA. How to DOWNLOAD a PRINTABLE PDF: You may print a single copy of this network diagram for personal or educational purposes. You must agree to preserve all elements of the image, including the copyright notice, web address, and creator's name. *But wait!* Do not download the image displayed above on this page; it is in PNG file format, which is not ideal for high-quality printing. Please see below to download a high-quality PDF file, formatted for printing on large-format paper, 36 x 48 inches (91 x 121 cm). You may adjust your software to print a larger or smaller image. Also download two files formatted to print the explanatory information on 11 x 17 inch paper. [ Click Here to Download the Wall Chart ==> acbig.pdf 324 kB ] [ Click Here to Download the Color Key ==> acolorkey.pdf 32 kB ] [ Click Here to Download the page with "Getting Started" and "Abbreviations" ==> acblack.pdf 104 kB ] After you print it, please send an email to tell us where the poster is displayed. COPYRIGHT and PRESENTATION HISTORY: Earlier versions of this network model were presented by John D. Furber in lectures or poster sessions at the following meetings: Symposium on the Systems Biology of Human Aging, National Institute on Aging, Baltimore, Maryland, 8-9 December 2009) Gerontological Society of America (Atlanta, Georgia, 21-25 November 2009) Manhattan Beach Project Longevity Summit 2009, (Manhattan Beach, California, 13-15 November 2009) http://www.manhattanbeachproject.com/ Strategies for Engineered Negligible Senescence (SENS4), Fourth Conference (Queens' College, Cambridge, England, September 2009) American Aging Association (Scottsdale, Arizona, May-June 2009) Symposium on the Systems Biology of Human Aging (Arizona State University, Tempe, Arizona, 6-7 December 2008) 6th European Congress of Biogerontology 2008 (Noordwijkerhout, The Netherlands, 30 November - 3 December 2008) Gerontological Society of America (Washington DC, 21-25 November 2008) NIH Mitochondria Mini-symposium (Bethesda, Maryland, 19 November 2008) Collaborative Drug Discovery (UCSF Mission Bay Campus, San Francsico, 7 October 2008) Understanding Aging: Biomedical and Bioengineering Approaches (UCLA, California, 27-29 June 2008) 2nd International Genome Dynamics in Neuroscience Conference. "Genome Dynamics and Instability in the Aging brain" (Asilomar Conference Center, California, 13-17 June 2008) American Aging Association (Boulder, Colorado, May-June 2008) Gordon Research Conference on Autophagy In Stress, Development & Disease, (Ventura, California, January 2008) Gerontological Society of America (San Francisco, November 2007) Buck Institute Symposium 2007, Buck Institute for Age Research (Novato, California, November 2007) Gordon Research Conference on the Biology of Aging, (Les Diablerets, Switzerland, September 2007) Department of Pharmacology, Linköping University, (Linköping, Sweden, September 2007) Strategies for Engineered Negligible Senescence (SENS3), Third Conference (Queens' College, Cambridge, England, September 2007) American Aging Association (San Antonio, Texas, June 2007) Edmonton Aging Symposium (Edmonton, Alberta,Canada, March 2007) European Conference on Aging, ECONAG 2006 (Innsbruck, Austria, November 2006) Gerontological Society of America (Dallas, Texas, November 2006) American Aging Association (Boston, Massachusetts, June 2006) The Simons Center for Systems Biology & Kavli Institute for Theoretical Physics Conference: "Determination of Longevity", (Institute for Advanced Study, Princeton, New Jersey, May 2006) Oxygen Club of California (Santa Barbara, March 2006) Gordon Research Conference on the Biology of Aging: "From Cells to Centenarians: New Concepts, Old Problems" (Ventura, California, January - February 2006) Gerontological Society of America (Orlando, Florida, November 2005) San Antonio Nathan Shock Aging Center Conferences on Aging: "The Role of Protein Misfolding and Aggregation on Aging and Age-Related Disorders," (Banderas, Texas, October 2005) Strategies for Engineered Negligible Senescence (SENS2), Second Conference (Queens' College, Cambridge, England, September 2005) International Association of Biomedical Gerontology, 11th Congress, "Understanding and Modulating Ageing" (Aarhus, Denmark, August 2005) American Aging Association (Oakland, California, June 2005) Gerontological Society of America (Washington DC, November 2004) International Association of Biomedical Gerontology, 10th Congress: "Strategies for Engineered Negligible Senescence: Reasons Why Genuine Control of Aging may be Foreseeable" (Queens' College, Cambridge, England, September 2003) Los Angeles Gerontology Research Group (Los Angeses, August 2003) American Aging Association (Baltimore, June 2003) Department of Pathology, Linköping University, (Linköping, Sweden, October 2002) SMi Conference Series, "Anti-Ageing Therapies," (London, England, October 2002) Strategic Research Institute, "Anti-Aging Drug Discovery and Development Summit: The Molecular Basis of Aging and Commercial Prospects for Therapeutics in Aging Intervention." (San Francisco, October 2002) American Aging Association (San Diego, June 2002) Oxygen Club of California (Santa Barbara, March 2002) Smart Life Forum (Palo Alto, California, December 2001) Gerontological Society of America (Chicago, November 2001) Center for Research and Education on Aging (CREA) "The New Science of Aging: A Symposium and Fair," (Berkeley, California, October 2001) International Association of Biomedical Gerontology, 9th Congress (Vancouver, Canada, June 2001) American Aging Association (Madison, Wisconsin, June 2001)
Please Send Suggestions for Improvements: Please email us if you see errors to correct, or if you can suggest ways to improve the clarity or utility of this Network Model as a tool for teaching or research. Please also tell us if you are using it in your classroom, research institute, or clinic. Write johnfurber at LegendaryPharma com.


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