Systems Biology of Human Aging
Network Model
Biochemical and Physiological Interactions

 
Please scroll down past the image to see:
  • Getting started with this Network Diagram;
  • Acknowledgements and Citations;
  • This network model has been reviewed by others;
  • How to order poster prints;
  • How to download a printable PDF;
  • Copyright and Presentation History.
  • How to suggest changes and improvments;
 
[Click here for smaller view.]
 
 
GETTING STARTED WITH THIS NETWORK DIAGRAM: This symbolic diagram is not really a picture of a cell. It changes in scale from molecular events at the top, through whole cell activities in the middle, to tissue, organ, and whole body diseases at the bottom. Thick horizontal borders separate transitions in scale. Intracellular events are described on the top left. Extracellular matrix and blood are described on the top right. Colors have meaning, as indicated in the "Color Key". Shapes have meanings described in the "Shape Key". A table of abbreviations is on the lower left. Solid boxes represent physical materials. Slanted-roof boxes represent increase or decrease in quantities during aging. Hatched boxes represent activities or processes. Thin arrows represent causal sequences of events. Thick arrows represent physical transport or movement. A circle with an "X" inside represents inhibition of the indicated process; this might mark a candidate target for therapeutic intervention. Tags on the outsides represent environmental factors or external interventions.
 
 
 
ACKNOWLEDGEMENTS and CITATIONS: This Network Model of Human Senescence was compiled and arranged by John D. Furber, based upon information in research reports from many scientists. References and links to more information about these topics may be found at: Keywords may be searched at: A very good recent review of aging mechanisms was published in the journal, Nature by Jan Vijg & Judith Campisi. (2008) Puzzles, promises and a cure for ageing. Nature, 454, 1065-1071.

Special thanks go to the following scientists for their helpful suggestions on earlier versions of this network diagram, which were used to update it to its current form:
Alexandra Stolzing, Aubrey de Grey, Pat Langley, Ulf T. Brunk, Alexei Terman, Caleb Finch, George M. Martin, Mark A. Smith, Richard G. Cutler, Florian Muller, Robert Bradbury, James Joseph, Mark P. Mattson, Allen Herbst, Arthur Balin, Bill Vaughan, Juraj Dzifcak, Stanley Primmer, Stephen A. Racunas.

 
This Network Model has been reviewed by others:

ORDERING POSTER PRINTS:
Full-color copies of this chart, printed on white background, may be ordered from Legendary Pharmaceuticals.

  • Large Wall Chart The network is printed on a large sheet, 36 x 48 inches (91 x 121 cm). The descriptive information is printed on two smaller sheets. Shipped rolled in a 36-inch mailing tube. $60 each plus $20 for shipping in the United States. Please enquire for foreign orders.
  • Medium Wall Chart The network is printed on a large sheet, 24 x 36 inches (61 x 91 cm). The descriptive information is printed on two smaller sheets. Shipped rolled in a 25-inch mailing tube. $40 each plus $15 for shipping in the United States. Please enquire for foreign orders.
  • Small Wall Chart The network is printed on a tabloid sheet of 11 x 15 inch white paper (28 x 38 cm). The descriptive information is printed on two separate sheets. Shipped rolled in a 12-inch mailing tube. At this reduced size, the text is very small, and difficult to read. $5 each plus $7 per order for packing & shipping. Please enquire for foreign orders.
  • Artist signature: Upon request, the artist will autograph your copy (no extra charge).
  • Sponsored Printing: Your organization or company can cover the cost of printing a batch of posters on large-format paper. An acknowledgment and your logo can be printed on the posters. This will lower the cost to scientists, students, and interested individuals. You can also distribute posters directly.
  • To enquire regarding larger sizes, quantity discounts, classroom use, sponsorship, or foreign addresses,
    please email: johnfurber at LegendaryPharma com
  • Please make checks payable to "Legendary Pharmaceuticals", and send to:
    Legendary Pharmaceuticals
    PO BOX 14200
    Gainesville FL 32604-2200, USA.
How to DOWNLOAD a PRINTABLE PDF:
You may print a single copy of this network diagram for personal or educational purposes. You must agree to preserve all elements of the image, including the copyright notice, web address, and creator's name.
But wait! Do not download the image displayed above on this page; it is in PNG file format, which is not ideal for high-quality printing. Please see below to download a high-quality PDF file, formatted for printing on large-format paper, 36 x 48 inches (91 x 121 cm). You may adjust your software to print a larger or smaller image.
Also download two files formatted to print the explanatory information on 11 x 17 inch paper.
  • [ Click Here to Download the Wall Chart ==> acbig.pdf 324 kB ]
  • [ Click Here to Download the Color Key ==> acolorkey.pdf 32 kB ]
  • [ Click Here to Download the page with "Getting Started" and "Abbreviations" ==> acblack.pdf 104 kB ]
After you print it, please send an email to tell us where the poster is displayed.

COPYRIGHT and PRESENTATION HISTORY:
Earlier versions of this network model were presented by John D. Furber in lectures or poster sessions at the following meetings:

Please Send Suggestions for Improvements: Please email us if you see errors to correct, or if you can suggest ways to improve the clarity or utility of this Network Model as a tool for teaching or research. Please also tell us if you are using it in your classroom, research institute, or clinic.
Write johnfurber at LegendaryPharma com.
 

[Flow Chart - Systems Biology of Aging]
[Extracellular Glycation and Crosslinks]
[Legendary Home Page] [Company Information] [Background: The Biology of Aging]
[Research Program] [Scientific Advisory Board] [Contact Information]

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